Patent flag
=============

Patent and article derived chemical databases are widely utilized for the evaluation of novelty.
In the case of the DiaDEM platform, our initial expectation is that literature data could have a lower relevance than patent-based data,
as many of the research articles show molecules that are not patented or a different application is demonstrated,
which does not limit the use as an organic electronic material.
The SureChEMBL [1]_ database currently contains ~17M structures, covering European, American, Japanese and world patents.

Although chirality and tautomer forms could be important factors in the working mechanisms of an active agent or a drug-like molecule,
patentability is mainly covered for the core chemical structure, and usually all stereoisomers and tautomers are covered with the same application.
Therefore, for the comparison we selected Sp2- level matching, based on generated InChIs and in case of matched we have **flagged** the relevant compounds.

.. [1] George Papadatos et al, Nucleic Acids Res. 2016 Jan 4; 44(Database issue): D1220–D1228. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702887/